Glutathione 98%

Introduction

Glutathione (GSH), also known as reduced glutathione, is mainly composed of glutamic acid, cysteine and glycine. Almost every cell in the human body has glutathione It also exists widely in animals and plants (such as wheat germ, radish, cherry tomatoes, tomatoes, animal liver, etc.) and in microorganisms.

Glutathione 98% has two forms, reduced (G-SH) and oxidized (G-S-S-G). Reduced glutathione can synthesize oxidized glutathione. Because oxidized glutathione accounts for a small amount, its Physiological activity is very low and almost ineffective, so the commonly known glutathione is usually reduced glutathione, and the main role is also reduced glutathione.

Glutathione is an active polypeptide with important physiological functions. Its molecular structure contains a sulfhydryl structure, so it has the biological activity of scavenging free radicals. Therefore, glutathione is used in cosmetics, medicine, health care products and other industries. Has a wide range of applications.

At present, there are four main methods for preparing glutathione in industrial production: enzymatic synthesis, solvent extraction, chemical synthesis and fermentation. Our company uses the enzyme synthesis method to prepare glutathione, and the obtained product has high purity, little environmental pollution and good cost performance.

Certificate of Analysis

Item	Specification	Results
Assay
Assay	98.0%~101.0%	98.80%(HPLC)
Physical & Chemical
Appearance	White crystal or crystalline powder	Conforms
Optical Rotation	-15.5°~ -17.5°	-16.2°
Bulk Density	Not less than 0.2 g/ml	0.48 g/ml
Tapped Density	Not less than 0.4 g/ml	0.78 g/ml
Identification IR	Similar with the reference spectrum	Complies
Clearity and color of solution	Clear and colourless	Complies
Chlorides	Not more than 200ppm	Complies
Sulphates	Not more than 300ppm	Complies
Ammonium	Not more than 200ppm	Complies
Iron	Not more than 10ppm	Complies
Loss on Drying	Not more than 0.5%	0.14%
Residue on ignition	Not more than 0.1%	0.08%
Chemical Control
Heavy Metals	NMT10ppm	Conforms
Lead(Pb)	NMT2ppm	Conforms
Arsenic (As)	NMT1ppm	Conforms
Mercury(Hg)	NMT0.5ppm	Conforms
Cadmium(Cd)	NMT0.5ppm	Conforms
Related Substances
Total	Not more than 2.0%	0.61%
GSSG	Not more than 1.5%	0.14%
Microbiological Specifications
Total Plate Count	1,000cfu/g Max	Conforms
Yeast & Mold	100cfu/g Max	Conforms
E.Coli	100 cfu/g Max	Conforms
Salmonella	Negative	Conforms

Glutathione 98% Flow Chart

Function

1. Detoxification: combine with poisons or drugs to eliminate their toxic effects;

Glutathione 98% is a sulfhydryl-containing tripeptide combined with glutamic acid, cysteine and glycine, and has antioxidant and integrated detoxification effects. The sulfhydryl group on cysteine is the active group of glutathione (so glutathione is often abbreviated as G-SH), which is easy to interact with certain drugs (such as paracetamol), toxins (such as free radicals, iodoacetic acid, mustard gas, lead, mercury, arsenic and other heavy metals), and has integrated detoxification effect. Therefore, glutathione (especially glutathione in liver cells) can participate in biotransformation, so as to convert harmful toxins in the body into harmless substances and excrete them out of the body. Glutathione also helps maintain normal immune system function

2. Participate in redox reactions: As an important reducing agent, it participates in various redox reactions in the body;

3. Protect the activity of thiolase: keep the active group-SH of thiolase in a reduced state;

4. Maintain the stability of the red blood cell membrane structure: eliminate the damaging effect of oxidants on the red blood cell membrane structure.

Application

1. Applied to dietary supplements;

Nordic Clinical, a US company, recently launched the N-O BloodBoost supplement, a mixture of glutathione and citrulline, which combines glutathione, citrulline, trans-resveratrol and another powerful antioxidant substance. Combined together, they can quickly enhance blood flow in the body, increasing the level of nitric oxide in the body, which in turn promotes blood circulation and provides the body with oxygen and some other important nutrients. This combination formula is a major breakthrough in the research of nitric oxide production. Although the formula composition seems simple, its efficacy cannot be ignored, especially for most patients over 40 years old.

In addition, NOW Foods USA has launched a new Setria glutathione vegetarian capsule, which combines milk thistle extract and alpha-lipoic acid to provide powerful glutathione at the cellular level. Antioxidant protection and liver protection.

2. Applied to medicines;

3. Widely used in cosmetics.

Advantage

At present, the industrially produced glutathione is mainly prepared by enzymatic synthesis, which has high purity and good water solubility. Reduced glutathione 98% produced by our company belongs to cosmetic grade, has good water solubility, and is convenient to be used in various cosmetics.

In addition to cosmetic grades, our company also has pharmaceutical grades that meet EP standards that can be used in the pharmaceutical industry, and can be applied to various detoxification and antioxidant drugs.

Safety

1. The American Cosmetic Association (CTFA) lists glutathione as a cosmetic raw material;

2. The 2010 edition of the "International Cosmetic Raw Materials Standard English Name Catalogue" issued by the China Fragrance Association and the "Announcement on the Catalogue of the Names of Cosmetic Raw Materials Used" issued by the China Food and Drug Administration in 2014 also use glutathione as a cosmetic raw material, and There are no reports that it is not safe for external use.

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